TABLET
Types of tablet:
A. Immediate release tablets: The tablet is intended to release rapidly after administration, or the tablet is dissolved and administered as solution.
Most common types are:
- Disintegrating tablets
- Chewable tablets
- Effervescent tablet
- Sublingual and buccal tablets
- Lozenges
Classification of lubricants:
Insoluble
Lubricants
|
Concentration
|
Comments
|
Stearate(magnesium
S., Calcium S., Sodium s.)
|
0.25-1
|
Reduce
tablet strength, prolong disintegration, widely used.
|
Talc
|
1-2
|
Insoluble
but not hydrophobic
|
Glycerylbehapate
|
1-5
|
Both
lubricant and Binder
|
Liquid
paraffin
|
Up
to 5
|
Dispersion
problem, inferior to stearate.
|
List of water soluble lubricants:
Water
soluble lubricants
|
Concentration
range (%w/w)
|
Boric
acid
|
1
|
Sodium
benzoate
|
5
|
Sodium
oleate
|
5
|
Sodium
acetate
|
5
|
Sodium
Lauryl sulphate(SLS)
|
1-5
|
Magnesium
lauryl sulphate (MLS)
|
1-2
|
BINDERS:
Binders or adhesives are the substances that promote cohesiveness. It is utilized for converting powder into granules through a process known as granulation.
Classification of binders:
|
Sugars
|
Natural binders
|
Synthetic/Semi-synthetic Polymer
|
|
Sucrose
|
Acacia
|
Methyl
cellulose
|
|
Liquid
glucose
|
Tragacanth
|
Ethyl
cellulose
|
|
|
Gelatin
|
Hydroxy
Propyl Methyl Cellulose(HPMC)
|
|
|
Strach
paste
|
Hydroxy
Propyl Cellulose(HPC)
|
|
|
Pregelatinised
starch
|
Sodium
Carboxy Methyl Cellulose
|
|
|
Alginic
Acid
|
Polyvinyl
Pyrrolidone
|
|
|
Cellulose
|
Polyethylene
glycol(PEG)
Polyvinyl
Alcohols, Poly methacrylates.
|
